Oxygen and retinopathy of prematurity

Oxygen free radicals and retinopathy of prematurity.

Retinopathy of prematurity: oxygen dogma challenged.

[Retinopathy of prematurity and oxygen therapy: a changing relationship].

INTRODUCTION The use of oxygen was implemented in neonatal practice in the absence of any randomized studies. The dose was (and still is in some places) not measured well. Additionally, the newborn’s oxygenation levels were not measured routinely until Arterial Blood Gases (ABG’s), capillary samples, transcutaneous PO2 (TcPO2) and, more recently, monitoring of oxygen saturation by pulse oximetr...

Current Concepts of Oxygen Management in Retinopathy of Prematurity

Retinopathy of prematurity (ROP) is a potentially blinding disorder in premature infants. The underlying pathophysiology is incompletely understood, limiting the prevention and treatment of this devastating condition. Current therapies are directed toward management of aberrant neovascularization thought to result from retinal ischemia in the developing preterm retina. The molecular mediators i...

Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity.

PURPOSE Identification of unique proteins involved in retinopathy of prematurity (ROP) may facilitate new and more effective diagnostic tools and molecular-based treatments for ROP. Tubedown-1 (Tbdn-1), a novel homeostatic protein which copurifies with an acetyltransferase activity, is expressed in normal retinal endothelium and is specifically suppressed in retinal endothelial cells from patie...